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Tumor‐Homing Poly‐siRNA/Glycol Chitosan Self‐Cross‐Linked Nanoparticles for Systemic siRNA Delivery in Cancer Treatment
Author(s) -
Lee So Jin,
Huh Myung Sook,
Lee Seung Young,
Min Solki,
Lee Seulki,
Koo Heebeom,
Chu JunUk,
Lee Kyung Eun,
Jeon Hyesung,
Choi Yongseok,
Choi Kuiwon,
Byun Youngro,
Jeong Seo Young,
Park Kinam,
Kim Kwangmeyung,
Kwon Ick Chan
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201201390
Subject(s) - chitosan , small interfering rna , nanoparticle , gene knockdown , in vivo , nanotechnology , chemistry , transfection , materials science , biochemistry , biology , gene , microbiology and biotechnology
The condensed version : Thiolated glycol chitosan can form stable nanoparticles with polymerized siRNAs through charge–charge interactions and self‐cross‐linking (see scheme). This poly‐siRNA/glycol chitosan nanoparticles (psi‐TGC) provided sufficient in vivo stability for systemic delivery of siRNAs. Knockdown of tumor proteins by psi‐TGC resulted in a reduction in tumor size and vascularization.