Total Synthesis of (−)‐13‐Oxyingenol and its Natural Derivative | Zendy

Ohyoshi Takayuki | Zendy; Funakubo Shota | Zendy; Miyazawa Yamato | Zendy; Niida Keisuke | Zendy; Hayakawa Ichiro | Zendy; Kigoshi Hideo | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Total Synthesis of (−)‐13‐Oxyingenol and its Natural Derivative

Author(s) -

Ohyoshi Takayuki,

Funakubo Shota,

Miyazawa Yamato,

Niida Keisuke,

Hayakawa Ichiro,

Kigoshi Hideo

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201201383

Subject(s) - derivative (finance) , total synthesis , ring (chemistry) , olefin metathesis , closing (real estate) , metathesis , stereochemistry , computer science , chemistry , combinatorial chemistry , organic chemistry , political science , business , polymerization , polymer , finance , law

Ring functionalization : The total synthesis of a natural derivative of (−)‐13‐oxyingenol, a potent anti‐HIV diterpenoid, is reported. The key steps in this synthesis include a ring‐closing olefin metathesis and a Mislow–Evans‐type [2,3]‐sigmatropic rearrangement. This synthesis provides access to (−)‐13‐oxyingenol and its natural derivative in 21 steps from a synthetic intermediate previously prepared by Kigoshi and co‐workers.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research