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Detergent‐Free Formation and Physicochemical Characterization of Nanosized Lipid–Polymer Complexes: Lipodisq
Author(s) -
Orwick Marcella C.,
Judge Peter J.,
Procek Jan,
Lindholm Ljubica,
Graziadei Andrea,
Engel Andreas,
Gröbner Gerhard,
Watts Anthony
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201201355
Subject(s) - polymer , lipid bilayer , dispersion (optics) , styrene , copolymer , chemistry , characterization (materials science) , polymer science , polymer chemistry , crystallography , chemical engineering , materials science , organic chemistry , nanotechnology , membrane , biochemistry , physics , optics , engineering
Lipodisq particles are polymer–lipid complexes formed by detergent‐free methods. Lipodisq particles containing dimyristoylphosphatidylcholine (DMPC) are characterized by increased lipid ordering compared to a DMPC dispersion. The styrene and maleic acid groups of the polymer interact with the DMPC lipid chains in bilayers, as well as lipid headgroups in the Lipodisq periphery (see picture).