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Imprinted Polymers Displaying High Affinity for Sulfated Protein Fragments
Author(s) -
Shinde Sudhirkumar,
Bunschoten Anton,
Kruijtzer John A. W.,
Liskamp Rob M. J.,
Sellergren Börje
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201201314
Subject(s) - molecularly imprinted polymer , peptide , polymer , sulfation , combinatorial chemistry , chemistry , computer science , elution , computational biology , chromatography , biochemistry , organic chemistry , biology , catalysis , selectivity
Leaving a lasting impression : Molecularly imprinted polymers (MIPs) featuring neutral binding sites for phosphotyrosine (P) is also shown to have affinity for sulfotyrosine (S) and a sulfotyrosine‐containing peptide. The MIPs were capable of selectively capturing both a phosphorylated and a sulfated peptide in a mixture and could release the peptides separately based on elution conditions.