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Catalytic Asymmetric Hydrogenation of Naphthalenes
Author(s) -
Kuwano Ryoichi,
Morioka Ryuichi,
Kashiwabara Manabu,
Kameyama Nao
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201201153
Subject(s) - enantioselective synthesis , ruthenium , catalysis , aromaticity , chemistry , alkoxy group , noyori asymmetric hydrogenation , organic chemistry , combinatorial chemistry , molecule , alkyl
Vanishing aromaticity : A chiral ruthenium complex catalyzes the hydrogenation of 2,6‐ or 2,7‐disubstituted naphthalenes to give chiral tetralins with up to 92 % ee. The chiral catalyst is applicable to the regio‐ and enantioselective reduction of 6‐substituted 2‐alkoxynaphthalenes and preferentially hydrogenates the alkoxy‐substituted arene rings.