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Multivalency as a Chemical Organization and Action Principle
Author(s) -
Fasting Carlo,
Schalley Christoph A.,
Weber Marcus,
Seitz Oliver,
Hecht Stefan,
Koksch Beate,
Dernedde Jens,
Graf Christina,
Knapp ErnstWalter,
Haag Rainer
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201201114
Subject(s) - realization (probability) , computer science , nanotechnology , non covalent interactions , simple (philosophy) , action (physics) , chemistry , biological system , biochemical engineering , cognitive science , molecule , materials science , biology , physics , engineering , mathematics , epistemology , psychology , hydrogen bond , statistics , philosophy , organic chemistry , quantum mechanics
Abstract Multivalent interactions can be applied universally for a targeted strengthening of an interaction between different interfaces or molecules. The binding partners form cooperative, multiple receptor–ligand interactions that are based on individually weak, noncovalent bonds and are thus generally reversible. Hence, multi‐ and polyvalent interactions play a decisive role in biological systems for recognition, adhesion, and signal processes. The scientific and practical realization of this principle will be demonstrated by the development of simple artificial and theoretical models, from natural systems to functional, application‐oriented systems. In a systematic review of scaffold architectures, the underlying effects and control options will be demonstrated, and suggestions will be given for designing effective multivalent binding systems, as well as for polyvalent therapeutics.