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Structure Formation and Catalytic Activity of DNA Dissolved in Organic Solvents
Author(s) -
Abe Hiroshi,
Abe Naoko,
Shibata Aya,
Ito Keiji,
Tanaka Yoshiyuki,
Ito Mika,
Saneyoshi Hisao,
Shuto Satoshi,
Ito Yoshihiro
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201201111
Subject(s) - hemin , chemistry , polyethylene glycol , peg ratio , catalysis , methanol , dna , solubilization , protoporphyrin ix , deoxyribozyme , combinatorial chemistry , organic chemistry , biochemistry , heme , enzyme , finance , photodynamic therapy , economics
Equal‐opportunity dissolver : By attaching polyethylene glycol at its 5′ end, DNA (PEG‐DNA) can be solubilized in various organic solvents and was shown to form G‐quadruplexes by CD spectroscopy. A complex containing iron(III) protoporphyrin IX (hemin) and G‐quadruplex‐forming PEG‐DNA catalyzed an oxidative reaction in methanol (see scheme).