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The Stereochemical Course and Mechanism of the IspH Reaction
Author(s) -
Citron Christian A.,
Brock Nelson L.,
Rabe Patrick,
Dickschat Jeroen S.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201201110
Subject(s) - isotopologue , mechanism (biology) , course (navigation) , path (computing) , chemistry , terpene , computer science , world wide web , information retrieval , stereochemistry , philosophy , computer network , engineering , organic chemistry , epistemology , molecule , aerospace engineering
On the right path : The stereochemcial course of the IspH reaction, the last reaction in the deoxyxylulose phosphate pathway to terpenes, was investigated in feeding experiments with deuterated isotopologues of 1‐deoxy‐ D ‐xylulose. The results support an enzyme mechanism for IspH that involves a previously suggested metallacyclopropane intermediate.