The Stereochemical Course and Mechanism of the IspH Reaction | Zendy

Citron Christian A. | Zendy; Brock Nelson L. | Zendy; Rabe Patrick | Zendy; Dickschat Jeroen S. | Zendy

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The Stereochemical Course and Mechanism of the IspH Reaction

Author(s) -

Citron Christian A.,

Brock Nelson L.,

Rabe Patrick,

Dickschat Jeroen S.

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201201110

Subject(s) - isotopologue , mechanism (biology) , course (navigation) , path (computing) , chemistry , terpene , computer science , world wide web , information retrieval , stereochemistry , philosophy , computer network , engineering , organic chemistry , epistemology , molecule , aerospace engineering

On the right path : The stereochemcial course of the IspH reaction, the last reaction in the deoxyxylulose phosphate pathway to terpenes, was investigated in feeding experiments with deuterated isotopologues of 1‐deoxy‐ D ‐xylulose. The results support an enzyme mechanism for IspH that involves a previously suggested metallacyclopropane intermediate.

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