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Human α 2 ‐Macroglobulin—Another Variation on the Venus Flytrap
Author(s) -
Meyer Cindy,
Hinrichs Winfried,
Hahn Ulrich
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201201104
Subject(s) - venus , macroglobulin , chemistry , mechanism (biology) , biophysics , biochemistry , biology , astrobiology , physics , quantum mechanics
Trapping proteinases : The mechanism of the nonspecific human proteinase inhibitor α 2 ‐macroglobulin (α 2 M, about 6000 amino acid residues) is reminiscent of a Venus flytrap (see scheme). The structure of α 2 M was solved recently with a resolution of 4.3 Å even though only one single crystal was available.