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Amide‐Forming Ligation of Acyltrifluoroborates and Hydroxylamines in Water
Author(s) -
Dumas Aaron M.,
Molander Gary A.,
Bode Jeffrey W.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201201077
Subject(s) - scope (computer science) , reagent , amide , substrate (aquarium) , ligation , scheme (mathematics) , computer science , combinatorial chemistry , chemistry , information retrieval , medicine , organic chemistry , mathematics , biology , surgery , programming language , ecology , mathematical analysis
Come together, right now : Acyltrifluoroborates and O ‐benzoyl hydroxylamines come together to form amides in water (see scheme). The ligations are complete within minutes at room temperature and do not require any reagents or catalysts. The reaction has a broad substrate scope and tolerates unprotected functional groups.