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Alkylation of Pyridone Derivatives By Nickel/Lewis Acid Catalysis
Author(s) -
Tamura Ryuichi,
Yamada Yuuya,
Nakao Yoshiaki,
Hiyama Tamejiro
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201200922
Subject(s) - carbene , alkylation , regioselectivity , chemistry , catalysis , nickel , alkyl , 2 pyridone , lewis acids and bases , nitrogen , organic chemistry , medicinal chemistry , combinatorial chemistry
MAD as an additive : The [Ni(cod) 2 ], (2,6‐ t Bu 2 ‐4‐MeC 6 H 2 O) 2 AlMe (MAD), and N‐heterocyclic carbene (NHC) catalytic system effected a highly regioselective alkylation of pyridone derivatives (see scheme). Substituted pyridones and related heterocycles react with both terminal and internal alkenes to selectively give a range of nitrogen‐containing heterocycles with linear alkyl substituents.