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Self‐Assembly of Thermally Responsive Nanoparticles of a Genetically Encoded Peptide Polymer by Drug Conjugation
Author(s) -
McDaniel Jonathan R.,
Bhattacharyya Jayanta,
Vargo Kevin B.,
Hassouneh Wafa,
Hammer Daniel A.,
Chilkoti Ashutosh
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201200899
Subject(s) - nanoparticle , biopolymer , drug delivery , polymer , nanotechnology , peptide , molecule , computer science , chemistry , covalent bond , combinatorial chemistry , materials science , biochemistry , organic chemistry
Nanoparticles on demand : Upon the site‐specific covalent attachment of hydrophobic molecules to one end of the biopolymer backbone, chimeric polypeptides (derived from elastin‐like polypeptides) can self‐assemble to form thermoresponsive nanoparticles suitable for drug delivery. Molecules with a distribution coefficient greater than 1.5 imparted sufficient amphiphilicity to drive self‐assembly into sub‐100 nm nanoparticles (see picture).