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A New Approach towards the Asymmetric Fluorination of Alkenes Using Anionic Phase‐Transfer Catalysts
Author(s) -
Hennecke Ulrich
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201200831
Subject(s) - alkene , catalysis , cationic polymerization , electrophile , chemistry , phase (matter) , combinatorial chemistry , enantioselective synthesis , organic chemistry
Chiral anions can do it : Asymmetric phase‐transfer catalysis is no longer limited to cationic catalysts. Lipophilic BINOL phosphate anions are superior catalysts for the asymmetric electrophilic fluorination of alkenes under phase‐transfer conditions (see picture). Now complex fluorinated compounds can be synthesized selectively from simple alkene starting materials.