Fully Integrated Thermoplastic Genosensor for the Highly Sensitive Detection and Identification of Multi‐Drug‐Resistant Tuberculosis | Zendy

Wang Hong | Zendy; Chen HuiWen | Zendy; Hupert Mateusz L. | Zendy; Chen PinChuan | Zendy; Datta Proyag | Zendy; Pittman Tana L. | Zendy; Goettert Jost | Zendy; Murphy Michael C. | Zendy; Williams Diana | Zendy; Barany Francis | Zendy; Soper Steven A. | Zendy

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Fully Integrated Thermoplastic Genosensor for the Highly Sensitive Detection and Identification of Multi‐Drug‐Resistant Tuberculosis

Author(s) -

Wang Hong,

Chen HuiWen,

Hupert Mateusz L.,

Chen PinChuan,

Datta Proyag,

Pittman Tana L.,

Goettert Jost,

Murphy Michael C.,

Williams Diana,

Barany Francis,

Soper Steven A.

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201200732

Subject(s) - tuberculosis , mycobacterium tuberculosis , medicine , nucleic acid amplification tests , drug resistance , polymerase chain reaction , virology , isoniazid , ligase chain reaction , bedaquiline , microbiology and biotechnology , biology , pathology , multiplex polymerase chain reaction , genetics , chlamydia trachomatis , gene

A modular system for the reporting of drug‐resistant strains of Mycobacterium tuberculosis (Mtb) in less than 30 min with full process automation was developed (see picture; MDR‐TB=multi‐drug‐resistant tuberculosis). The fluidic cartridge uses a polymer chain reaction (PCR)/ligase detection reaction (LDR)/universal array assay that can detect, with high reliability, resistant strains that are a minority (less than 1 %) from a mixed population.

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