Premium
Palladium‐Catalyzed Alkylation of 1,4‐Dienes by CH Activation
Author(s) -
Trost Barry M.,
Hansmann Max M.,
Thaisrivongs David A.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201200601
Subject(s) - nucleophile , alkylation , tsuji–trost reaction , catalysis , chemistry , palladium , diene , medicinal chemistry , sulfoxide , dimethyl sulfoxide , organic chemistry , natural rubber
Activated : The title reaction proceeds with a broad range of nucleophiles and variously substituted 1,4‐dienes under mild conditions, and provides direct access to the corresponding 1,3‐diene‐containing products with high regio‐ and stereocontrol (see scheme; 2,6‐DMBQ=2,6‐dimethylbenzoquinone, EWG=electron‐withdrawing group). This is the first catalytic allylic CH alkylation that proceeds in the absence of sulfoxide ligands.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom