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Chemical Probes for the Recognition of Cannabinoid Receptors in Native Systems
Author(s) -
MartínCouce Lidia,
MartínFontecha Mar,
Palomares Óscar,
Mestre Leyre,
Cordomí Arnau,
Hernangomez Miriam,
Palma Sara,
Pardo Leonardo,
Guaza Carmen,
LópezRodríguez María L.,
OrtegaGutiérrez Silvia
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201200467
Subject(s) - cannabinoid receptor , receptor , cannabinoid , neuroscience , g protein coupled receptor , immune system , biology , endocannabinoid system , microbiology and biotechnology , chemistry , biochemistry , immunology , agonist
Receptors made visible : The described biotin‐tagged small‐molecule probes with excellent affinities for the CB 1 and CB 2 cannabinoid receptors (CB 1 R and CB 2 R) enable direct visualization of these receptors in native cellular systems, including neurons (see picture), microglia, and immune cells. This method could overcome some of the limitations of current methodologies and may help to dissect the complexity of the endogenous cannabinoid system.