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Hybrid Nanomaterials that Mimic the Food Effect: Controlling Enzymatic Digestion for Enhanced Oral Drug Absorption
Author(s) -
Tan Angel,
Martin Amanda,
Nguyen TriHung,
Boyd Ben J.,
Prestidge Clive A.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201200409
Subject(s) - lipid digestion , nanotechnology , nanoparticle , chemistry , nanomaterials , mesoporous silica , emulsion , absorption (acoustics) , digestion (alchemy) , mesoporous material , materials science , enzyme , chromatography , biochemistry , lipase , composite material , catalysis
Easily digested : SiO 2 –lipid hybrid microparticles with specific nanostructured interiors were generated from submicrometer‐sized emulsion templates based on mesoporous and non‐porous silica nanoparticles. These functional lipid‐based microparticles can be used to mimic the pharmaceutical food effect and enhance drug absorption by controlling the enzymatic digestion of lipid colloids (see scheme; ○ oil solution, ▴ lipid–nanoparticle hybrid, □ lipid encapsulated in hybrid).