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Gold‐Catalyzed Carbene Transfer to Alkynes: Access to 2,4‐Disubstituted Furans
Author(s) -
Kramer Søren,
Skrydstrup Troels
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201200307
Subject(s) - carbene , intramolecular force , cycloaddition , catalysis , intermolecular force , chemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , molecule
Furans of gold : The first example of a gold‐catalyzed intermolecular addition of carbon ylides to terminal alkynes is reported (see scheme; DCE=dichloroethane, Tf=trifluoromethanesulfonyl). Subsequent intramolecular trapping of the generated gold carbene completes a formal [3+2] cycloaddition, which represents a novel synthesis of 2,4‐disubstituted furans.