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A General Pd‐Catalyzed Decarboxylative Cross‐Coupling Reaction between Aryl Carboxylic Acids: Synthesis of Biaryl Compounds
Author(s) -
Hu Peng,
Shang Yaping,
Su Weiping
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201200153
Subject(s) - aryl , chemistry , catalysis , trifluoromethyl , decarboxylation , carboxylic acid , combinatorial chemistry , coupling reaction , nitro , organic chemistry , alkyl
Acid to acid : A general method has been developed for the synthesis of biaryl compounds through a decarboxylative cross‐coupling reaction between two different (hetero)aryl carboxylic acids (see scheme). The use of a Pd II /PCy 3 catalyst enables the cross‐coupling reaction of electronically different or electronically similar aryl carboxylic acids. This method is compatible with substrates having nitro, cyano, fluoro, chloro, bromo, trifluoromethyl, and methoxy substituents.