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Copper‐Catalyzed Di‐ and Trifluoromethylation of α,β‐Unsaturated Carboxylic Acids: A Protocol for Vinylic Fluoroalkylations
Author(s) -
He Zhengbiao,
Luo Tao,
Hu Mingyou,
Cao Yanjing,
Hu Jinbo
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201200140
Subject(s) - trifluoromethylation , electrophile , chemistry , catalysis , lewis acids and bases , organic chemistry , carboxylic acid , trifluoromethyl , combinatorial chemistry , medicinal chemistry , alkyl
Dual action : The Lewis acid CuF 2 ⋅2 H 2 O efficiently catalyzes the reaction between electrophilic fluoroalkylating agents and α,β‐unsaturated carboxylic acids by dually activating both reactants, thus affording di‐ and trifluoromethyl alkenes in high yields with excellent E / Z selectivity.