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Palladium‐Catalyzed Aromatic Azidocarbonylation
Author(s) -
Miloserdov Fedor M.,
Grushin Vladimir V.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201200078
Subject(s) - xantphos , xanthene , palladium , catalysis , yield (engineering) , chemistry , aryl , medicinal chemistry , organic chemistry , materials science , alkyl , metallurgy
Aryl iodides smoothly react with NaN 3 and CO in the presence of a Pd/Xantphos catalyst to give aroyl azides (ArCON 3 ) in 75–92 % yield. The reaction occurs under mild reaction conditions (1 atm, 20–50 °C) and exhibits high functional‐group tolerance. (Xantphos=9,9‐dimethyl‐4,5‐bis(diphenylphosphino)xanthene)