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Assembly and Absolute Configuration of Short‐Lived Polyketides from Burkholderia thailandensis
Author(s) -
Ishida Keishi,
Lincke Thorger,
Hertweck Christian
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201200067
Subject(s) - absolute configuration , polyketide , stereochemistry , burkholderia , chemistry , computational biology , biosynthesis , computer science , biology , biochemistry , genetics , bacteria , gene
Decoded before decay : Cryptic and highly unstable polyketide metabolites, thailandamides A and B, were isolated from Burkholderia thailandensis , and their absolute configurations fully elucidated using a combination of chemical degradation, bioinformatics, NMR spectroscopy, precursor‐directed biosynthesis, and analysis of pathway intermediates (see scheme).