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Mild and Efficient C2‐Alkenylation of Indoles with Alkynes Catalyzed by a Cobalt Complex
Author(s) -
Ding Zhenhua,
Yoshikai Naohiko
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201200019
Subject(s) - denticity , cobalt , phosphine , catalysis , pyridine , stereoselectivity , ligand (biochemistry) , substrate (aquarium) , chemistry , combinatorial chemistry , scope (computer science) , computer science , organic chemistry , programming language , receptor , biochemistry , oceanography , crystal structure , geology
Direct alkenylation of the C2‐position of indoles bearing an easily removable N‐pyrimidyl group with alkynes has been achieved by using a cobalt catalyst complexed with a phosphine–pyridine bidentate ligand. This reaction has wide substrate scope and is highly efficient and stereoselective at room temperature. The alkenylated indoles serve as useful platforms for further synthetic transformations (some products of these transformations are shown in the scheme).