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Molecular Scaffolds Using Multiple Orthogonal Conjugations: Applications in Chemical Biology and Drug Discovery
Author(s) -
Beal David M.,
Jones Lyn H.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201200002
Subject(s) - drug discovery , chemical biology , nanotechnology , synthetic biology , computational biology , computer science , biochemical engineering , biology , materials science , engineering , bioinformatics , genetics
Heteromultifunctional scaffolds that harness sequential “click” reactions will find significant utility in the areas of chemical biology and chemically enabled/enhanced biotherapeutics (“chemologics”). Here we review the existing synthetic technologies that illustrate the considerable potential of the field.