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A Photochromic Agonist of AMPA Receptors
Author(s) -
Stawski Philipp,
Sumser Martin,
Trauner Dirk
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201109265
Subject(s) - ampa receptor , ionotropic effect , agonist , long term depression , chemistry , receptor , glutamate receptor , neuroscience , photochromism , kainate receptor , biophysics , pharmacology , biology , biochemistry , photochemistry
Light switch : A photochromic agonist ATA‐3 (see scheme) of AMPA receptors, arguably the most important class of ionotropic glutamate receptors, is shown to be subtype selective, activates the AMPA receptor GluA2 in the dark, and is quickly turned off when irradiated with blue–green light. It can be used to effectively control neuronal activity in the mammalian brain.