Premium
2‐Aminobenzimidazole Derivatives Strongly Inhibit and Disperse Pseudomonas aeruginosa Biofilms
Author(s) -
Frei Reto,
Breitbach Anthony S.,
Blackwell Helen E.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201109258
Subject(s) - quorum sensing , biofilm , pseudomonas aeruginosa , microbiology and biotechnology , antibiotics , chemistry , bacteria , biology , computational biology , genetics
Bacterial biofilms are exceptionally difficult to clear using traditional antibiotics and constitute a significant health threat. 2‐Aminobenzimidazole derivatives (see scheme) are capable of strongly inhibiting the growth of and dispersing Pseudomonas aeruginosa biofilms. These molecules were found to modulate quorum sensing in reporter strains, and represent some of strongest P. aeruginosa biofilm inhibitors known.