Palladium‐Catalyzed Direct CH Arylation of Enamides with Simple Arenes | Zendy

Pankajakshan Sreekumar | Zendy; Xu YunHe | Zendy; Cheng Jun Kee | Zendy; Low Man Ting | Zendy; Loh TeckPeng | Zendy

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Palladium‐Catalyzed Direct CH Arylation of Enamides with Simple Arenes

Author(s) -

Pankajakshan Sreekumar,

Xu YunHe,

Cheng Jun Kee,

Low Man Ting,

Loh TeckPeng

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201109247

Subject(s) - chemistry , palladium , olefin fiber , catalysis , combinatorial chemistry , atom economy , selectivity , reactivity (psychology) , substrate (aquarium) , organic chemistry , medicine , oceanography , alternative medicine , pathology , geology

Z only : An atom‐economical synthetic route towards arylated Z‐ enamides through double CH functionalization is described. The Z / E selectivity of the palladium‐catalyzed monoarylation is absolute (step A in scheme), and the molecular complexity of the products can be further endowed by a sequential second arylation, which requires the use of trifluoracetic acid (TFA; step B).

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