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Palladium‐Catalyzed Direct CH Arylation of Enamides with Simple Arenes
Author(s) -
Pankajakshan Sreekumar,
Xu YunHe,
Cheng Jun Kee,
Low Man Ting,
Loh TeckPeng
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201109247
Subject(s) - chemistry , palladium , olefin fiber , catalysis , combinatorial chemistry , atom economy , selectivity , reactivity (psychology) , substrate (aquarium) , organic chemistry , medicine , oceanography , alternative medicine , pathology , geology
Z only : An atom‐economical synthetic route towards arylated Z‐ enamides through double CH functionalization is described. The Z / E selectivity of the palladium‐catalyzed monoarylation is absolute (step A in scheme), and the molecular complexity of the products can be further endowed by a sequential second arylation, which requires the use of trifluoracetic acid (TFA; step B).