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Back Cover: Enantioselective Alkynylbenzaldehyde Cyclizations Catalyzed by Chiral Gold(I) Acyclic Diaminocarbene Complexes Containing Weak Au–Arene Interactions (Angew. Chem. Int. Ed. 12/2012)
Author(s) -
Handa Sachin,
Slaughter LeGrande M.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201109229
Subject(s) - enantioselective synthesis , cycloisomerization , catalysis , carbene , chemistry , stereochemistry , atom (system on chip) , crystallography , organic chemistry , computer science , embedded system
Creating an asymmetric environment at Au I is a challenge because of the linear coordination geometry of the ion. In their Communication on page 2912 ff., S. Handa and L. M. Slaughter report the highly enantioselective catalysis of a tandem addition/cycloisomerization reaction of alkynylbenzaldehydes by chiral gold carbene complexes containing weak metal–π interactions. These secondary interactions help to create an asymmetric pocket around the gold atom that is analogous to a baseball glove gripping a ball. (Picture by L. M. Slaughter and S. Ball.)