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A Sensitive Zinc‐Activated 129 Xe MRI Probe
Author(s) -
Kotera Naoko,
Tassali Nawal,
Léonce Estelle,
Boutin Céline,
Berthault Patrick,
Brotin Thierry,
Dutasta JeanPierre,
Delacour Léa,
Traoré Ténin,
Buisson DavidAlexandre,
Taran Frédéric,
Coudert Sylvie,
Rousseau Bernard
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201109194
Subject(s) - zinc , radiochemistry , chemistry , isotopes of zinc , nuclear magnetic resonance , physics , nuclear chemistry , organic chemistry
Xenon capsule : A smart 129 Xe NMR‐based sensor of Zn 2+ ions for magnetic resonance imaging (MRI) is proposed. The resonance frequency of xenon encapsulated in a cryptophane that bears a nitrilotriacetic ligand moiety varies when Zn 2+ ions are present in solution (see picture). With hyper‐polarized gas, such a construct enables detection of 100 n M zinc in one xenon batch, a threshold 300 times lower than achieved with gadolinium chelates.