Uncharacterized 4,5‐Dihydroxy‐2,3‐Pentanedione (DPD) Molecules Revealed Through NMR Spectroscopy: Implications for a Greater Signaling Diversity in Bacterial Species | Zendy

Globisch Daniel | Zendy; Lowery Colin A. | Zendy; McCague Karen C. | Zendy; Janda Kim D. | Zendy

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Uncharacterized 4,5‐Dihydroxy‐2,3‐Pentanedione (DPD) Molecules Revealed Through NMR Spectroscopy: Implications for a Greater Signaling Diversity in Bacterial Species

Author(s) -

Globisch Daniel,

Lowery Colin A.,

McCague Karen C.,

Janda Kim D.

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201109149

Subject(s) - nuclear magnetic resonance spectroscopy , bacteria , molecule , chemistry , autoinducer , spectroscopy , two dimensional nuclear magnetic resonance spectroscopy , cell signaling , stereochemistry , biochemistry , signal transduction , biology , organic chemistry , genetics , quorum sensing , physics , biofilm , quantum mechanics

Talking bacteria : The combination of NMR spectroscopy and 4,5‐dihydroxy‐2,3‐pentanedione (DPD) homologue analysis reveals that DPD, a bacterial signaling compound in the autoinducer‐2 (AI‐2) class (see scheme), exists as a much more complex structural array of molecules than previously appreciated. This finding suggests the existence of a larger bacterial chemical signaling language than previously thought.

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