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Uncharacterized 4,5‐Dihydroxy‐2,3‐Pentanedione (DPD) Molecules Revealed Through NMR Spectroscopy: Implications for a Greater Signaling Diversity in Bacterial Species
Author(s) -
Globisch Daniel,
Lowery Colin A.,
McCague Karen C.,
Janda Kim D.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201109149
Subject(s) - nuclear magnetic resonance spectroscopy , bacteria , molecule , chemistry , autoinducer , spectroscopy , two dimensional nuclear magnetic resonance spectroscopy , cell signaling , stereochemistry , biochemistry , signal transduction , biology , organic chemistry , genetics , quorum sensing , physics , biofilm , quantum mechanics
Talking bacteria : The combination of NMR spectroscopy and 4,5‐dihydroxy‐2,3‐pentanedione (DPD) homologue analysis reveals that DPD, a bacterial signaling compound in the autoinducer‐2 (AI‐2) class (see scheme), exists as a much more complex structural array of molecules than previously appreciated. This finding suggests the existence of a larger bacterial chemical signaling language than previously thought.