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Orthogonal Riboswitches for Tuneable Coexpression in Bacteria
Author(s) -
Dixon Neil,
Robinson Christopher J.,
Geerlings Torsten,
Duncan John N.,
Drummond Sheona P.,
Micklefield Jason
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201109106
Subject(s) - riboswitch , computational biology , computer science , control (management) , gene , information retrieval , scheme (mathematics) , biology , data mining , gene expression , genetics , artificial intelligence , mathematics , non coding rna , mathematical analysis
Orthogonal gene control : Orthogonal riboswitches can be deployed in the same bacterial cell to independently control the coexpression of multiple genes in a dose‐dependent response to distinct synthetic small molecules. This technique allows convenient access to highly dynamic expression landscapes and desirable protein stoichiometries.