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Inside Back Cover: In Vitro and In Vivo Uncaging and Bioluminescence Imaging by Using Photocaged Upconversion Nanoparticles (Angew. Chem. Int. Ed. 13/2012)
Author(s) -
Yang Yanmei,
Shao Qing,
Deng Renren,
Wang Chao,
Teng Xue,
Cheng Kai,
Cheng Zhen,
Huang Ling,
Liu Zhuang,
Liu Xiaogang,
Xing Bengang
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201109102
Subject(s) - photon upconversion , in vivo , bioluminescence imaging , bioluminescence , chemistry , biocompatible material , biophysics , in vitro , bioconjugation , luciferin , nanoparticle , nanotechnology , luciferase , biomedical engineering , materials science , biochemistry , biology , medicine , ion , transfection , microbiology and biotechnology , organic chemistry , gene
Bioconjugation of photocaged D ‐luciferin with upconversion nanoparticles (UCNPs) for uncaging and bioluminescence imaging is reported by X. Liu, B. Xing, and co‐workers in their Communication on page 3125 ff. Photon upconversion of near‐infrared light by the biocompatible UCNPs causes D ‐luciferin to be released from the surface of the UCNPs, thus resulting in enhanced bioluminescence signals in vitro and in vivo with deep light penetration and minimum cell damage.