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Scalable Total Synthesis of (−)‐Berkelic Acid by Using a Protecting‐Group‐Free Strategy
Author(s) -
Fañanás Francisco J.,
Mendoza Abraham,
Arto Tamara,
Temelli Baris,
Rodríguez Félix
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201109076
Subject(s) - scalability , computer science , simple (philosophy) , sequence (biology) , scale (ratio) , total synthesis , core (optical fiber) , group (periodic table) , database , chemistry , stereochemistry , organic chemistry , telecommunications , philosophy , biochemistry , physics , epistemology , quantum mechanics
Supply chain : The polycyclic core of (−)‐berkelic acid ( 1 ) was constructed in just one step from very simple starting materials. The total synthesis of 1 involves a seven‐step linear sequence. Protection/deprotection steps were avoided and all but the last step were performed on a gram scale. This synthesis could solve the supply problem associated with the exhaustion of the natural source.