Scalable Total Synthesis of (−)‐Berkelic Acid by Using a Protecting‐Group‐Free Strategy | Zendy

Fañanás Francisco J. | Zendy; Mendoza Abraham | Zendy; Arto Tamara | Zendy; Temelli Baris | Zendy; Rodríguez Félix | Zendy

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Scalable Total Synthesis of (−)‐Berkelic Acid by Using a Protecting‐Group‐Free Strategy

Author(s) -

Fañanás Francisco J.,

Mendoza Abraham,

Arto Tamara,

Temelli Baris,

Rodríguez Félix

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201109076

Subject(s) - scalability , computer science , simple (philosophy) , sequence (biology) , scale (ratio) , total synthesis , core (optical fiber) , group (periodic table) , database , chemistry , stereochemistry , organic chemistry , telecommunications , philosophy , biochemistry , physics , epistemology , quantum mechanics

Supply chain : The polycyclic core of (−)‐berkelic acid ( 1 ) was constructed in just one step from very simple starting materials. The total synthesis of 1 involves a seven‐step linear sequence. Protection/deprotection steps were avoided and all but the last step were performed on a gram scale. This synthesis could solve the supply problem associated with the exhaustion of the natural source.

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