Premium
Towards a Structural Basis for the Relationship Between Blood Group and the Severity of El Tor Cholera
Author(s) -
Mandal Pintu K.,
Branson Thomas R.,
Hayes Edward D.,
Ross James F.,
Gavín Jose A.,
Daranas Antonio H.,
Turnbull W. Bruce
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201109068
Subject(s) - cholera toxin , cholera , toxin , group a , isothermal microcalorimetry , group b , microbiology and biotechnology , chemistry , medicine , biology , biochemistry , stereochemistry , physics , quantum mechanics , enthalpy
It has long been known that people with blood group O are more severely affected by El Tor cholera than those with blood groups A or B. Microcalorimetry and NMR spectroscopy are used to evaluate the ability of the B‐subunits of cholera toxin and E. coli heat‐labile toxin to bind to selected blood group oligosaccharides.