Premium
Enantioselective Oxidative Cross‐Dehydrogenative Coupling of Tertiary Amines to Aldehydes
Author(s) -
Zhang Junmin,
Tiwari Bhoopendra,
Xing Chong,
Chen Xingkuan,
Chi Yonggui Robin
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201109054
Cooperative catalysts : An enantioselective and direct oxidative coupling of aldehydes to tertiary amines to give β‐amino alcohols is described. Catalyzed by copper(II), the reaction proceeds to give a racemic mixture of products; however, by using a combination of copper(II) and a chiral amine catalyst, the reaction gives the desired products with high enantioselectivity (see scheme).