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Chemical Synthesis of an Erythropoietin Glycoform Containing a Complex‐type Disialyloligosaccharide
Author(s) -
Murakami Masumi,
Okamoto Ryo,
Izumi Masayuki,
Kajihara Yasuhiro
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201109034
Subject(s) - erythropoietin , peptide , chemistry , amino acid , amino acid residue , biochemistry , peptide synthesis , combinatorial chemistry , peptide sequence , biology , gene , endocrinology
New and improved : New reaction conditions for tert ‐Boc‐based solid‐phase peptide synthesis make acid‐labile sialyloligosaccharyl peptide α‐thioesters accessible. To demonstrate this, a sialyloligosaccharyl‐erythropoietin glycoform (see picture) with 166 amino acid residues was synthesized.