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Copper‐Catalyzed CH Oxidation/Cross‐Coupling of α‐Amino Carbonyl Compounds
Author(s) -
Wu JiCheng,
Song RenJie,
Wang ZhiQiang,
Huang XiaoCheng,
Xie YeXiang,
Li JinHeng
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201109027
Subject(s) - aryl , catalysis , copper , chemistry , combinatorial chemistry , coupling (piping) , organic chemistry , materials science , alkyl , metallurgy
Keeping options open : The new and mild title reaction involving indoles selectively furnishes 1 and 2 with the aid of tert ‐butyl hydroperoxide (TBHP). The method represents the first example of a copper‐catalyzed α arylation of α‐amino carbonyl substrates leading to α‐aryl α‐imino and α‐aryl α‐oxo carbonyl compounds using a CH oxidation strategy.
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