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An Iron(III)–Monoamidate Complex Catalyst for Selective Hydroxylation of Alkane CH Bonds with Hydrogen Peroxide
Author(s) -
Hitomi Yutaka,
Arakawa Kengo,
Funabiki Takuzo,
Kodera Masahito
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201108933
Subject(s) - heterolysis , hydroxylation , hydrogen peroxide , chemistry , catalysis , radical , moiety , ligand (biochemistry) , combinatorial chemistry , alkane , peroxide , medicinal chemistry , photochemistry , organic chemistry , stereochemistry , biochemistry , receptor , enzyme
Selective oxidation : The success of the title reaction (see scheme) is caused by the strong electron donation from the amidate moiety of the dpaq ligand to the iron center (dpaq=2‐[bis(pyridin‐2‐ylmethyl)]amino‐ N ‐quinolin‐8‐yl‐acetamidate). This process facilitates the OO bond heterolysis of the intermediate Fe III OOH species to generate a selective oxidant without forming highly reactive hydroxyl radicals.