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Lithiation of 1,2‐Dichloroethene in Flow Microreactors: Versatile Synthesis of Alkenes and Alkynes by Precise Residence‐Time Control
Author(s) -
Nagaki Aiichiro,
Matsuo Chika,
Kim Songhee,
Saito Kodai,
Miyazaki Atsuo,
Yoshida Junichi
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201108932
Subject(s) - microreactor , residence time (fluid dynamics) , control (management) , chemistry , computer science , flow chemistry , residence , combinatorial chemistry , organic chemistry , catalysis , engineering , artificial intelligence , sociology , demography , geotechnical engineering
It′s all about the timing : Precise control of the residence time ( t R x ; see picture) of reactive intermediates in flow microreactors enables the reaction pathway of lithiated 1,2‐dichloroethene to be switched to produce either alkenes or alkynes. This method also allows versatile syntheses of asymmetric disubstituted dichloroalkenes and alkynes.