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A Unified Mechanism for Abiotic Adenine and Purine Synthesis in Formamide
Author(s) -
Hudson Jeremy S.,
Eberle Joseph F.,
Vachhani Raj H.,
Rogers Luther C.,
Wade James H.,
Krishnamurthy Ramanarayanan,
Springsteen Greg
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201108907
Subject(s) - purine , formamide , stereochemistry , mechanism (biology) , purine metabolism , chemistry , parallels , biochemistry , computer science , computational biology , information retrieval , biology , philosophy , organic chemistry , engineering , epistemology , enzyme , mechanical engineering
Form(am)idable beginning : Mechanistic pathways from formamide to purine and adenine have been proposed (see scheme, purine (R=H, X=H), adenine (R=CN, X=NH 2 , R′=CONH 2 ). Parallels between these plausible prebiotic syntheses and purine‐ring biosynthesis may allude to the origins of the metabolic route.