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Palladium‐Catalyzed Amidation by Chemoselective C(sp 3 )H Activation: Concise Route to Oxindoles Using a Carbamoyl Chloride Precursor
Author(s) -
Tsukano Chihiro,
Okuno Masataka,
Takemoto Yoshiji
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201108889
Subject(s) - palladium , catalysis , ligand (biochemistry) , chemistry , combinatorial chemistry , atmosphere (unit) , medicinal chemistry , organic chemistry , physics , receptor , biochemistry , thermodynamics
Quite select : A new strategy was developed for the synthesis of various oxindoles from carbamoyl chlorides. Under the optimum reaction conditions, with Ad 2 PBu as a ligand, t BuCONHOH as an additive, and a CO atmosphere, selective C(sp 3 )H activation proceeded in the presence of a C(sp 2 )H bond. Ad=adamantyl.