Palladium‐Catalyzed Amidation by Chemoselective C(sp 3 )H Activation: Concise Route to Oxindoles Using a Carbamoyl Chloride Precursor | Zendy

Tsukano Chihiro | Zendy; Okuno Masataka | Zendy; Takemoto Yoshiji | Zendy

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Palladium‐Catalyzed Amidation by Chemoselective C(sp 3 )H Activation: Concise Route to Oxindoles Using a Carbamoyl Chloride Precursor

Author(s) -

Tsukano Chihiro,

Okuno Masataka,

Takemoto Yoshiji

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201108889

Subject(s) - palladium , catalysis , ligand (biochemistry) , chemistry , combinatorial chemistry , atmosphere (unit) , medicinal chemistry , organic chemistry , physics , receptor , biochemistry , thermodynamics

Quite select : A new strategy was developed for the synthesis of various oxindoles from carbamoyl chlorides. Under the optimum reaction conditions, with Ad 2 PBu as a ligand, t BuCONHOH as an additive, and a CO atmosphere, selective C(sp 3 )H activation proceeded in the presence of a C(sp 2 )H bond. Ad=adamantyl.

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