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Decoupling Two‐Dimensional NMR Spectroscopy in Both Dimensions: Pure Shift NOESY and COSY
Author(s) -
Aguilar Juan A.,
Colbourne Adam A.,
Cassani Julia,
Nilsson Mathias,
Morris Gareth A.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201108888
Subject(s) - decoupling (probability) , two dimensional nuclear magnetic resonance spectroscopy , multiplet , covariance , spectral line , computer science , information retrieval , physics , nuclear magnetic resonance , mathematics , statistics , engineering , quantum mechanics , control engineering
An increase in the resolving power in 2D NMR spectra is obtained by collapsing 2D signals with multiplet structure into 2D singlets. This resolution gain is achieved by combining 2D experiments with pure shift techniques and covariance processing (see picture). The method should be of value in both manual and automated structure determination.