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The Art of Filling Protein Pockets Efficiently with Octahedral Metal Complexes
Author(s) -
Blanck Sebastian,
Maksimoska Jasna,
Baumeister Julia,
Harms Klaus,
Marmorstein Ronen,
Meggers Eric
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201108865
Subject(s) - phthalimide , colored , octahedron , ruthenium , staurosporine , metal , materials science , crystallography , chemistry , protein kinase a , crystal structure , organic chemistry , metallurgy , kinase , biochemistry , composite material , catalysis
Better fit, less effort : An easy‐to‐synthesize ruthenium phthalimide complex (tan‐colored carbon atoms in the picture) was designed to bind within the active site of the p21‐activated kinase 1 in a novel fashion that differs from that of the previously established staurosporine‐inspired metallopyridocarbazoles (gray‐colored carbon atoms).