The Art of Filling Protein Pockets Efficiently with Octahedral Metal Complexes | Zendy

Blanck Sebastian | Zendy; Maksimoska Jasna | Zendy; Baumeister Julia | Zendy; Harms Klaus | Zendy; Marmorstein Ronen | Zendy; Meggers Eric | Zendy

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The Art of Filling Protein Pockets Efficiently with Octahedral Metal Complexes

Author(s) -

Blanck Sebastian,

Maksimoska Jasna,

Baumeister Julia,

Harms Klaus,

Marmorstein Ronen,

Meggers Eric

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201108865

Subject(s) - phthalimide , colored , octahedron , ruthenium , staurosporine , metal , materials science , crystallography , chemistry , protein kinase a , crystal structure , organic chemistry , metallurgy , kinase , biochemistry , composite material , catalysis

Better fit, less effort : An easy‐to‐synthesize ruthenium phthalimide complex (tan‐colored carbon atoms in the picture) was designed to bind within the active site of the p21‐activated kinase 1 in a novel fashion that differs from that of the previously established staurosporine‐inspired metallopyridocarbazoles (gray‐colored carbon atoms).

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