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Regulation of Redox Potential of a Pterin Derivative Bound to a Ruthenium(II) Complex by Intermolecular Hydrogen Bonding with Nucleobases
Author(s) -
Inui Yuji,
Miyazaki Soushi,
Ohkubo Kei,
Fukuzumi Shunichi,
Kojima Takahiko
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201108827
Subject(s) - pterin , ruthenium , chemistry , adduct , hydrogen bond , nucleobase , intermolecular force , guanine , derivative (finance) , redox , ligand (biochemistry) , thymine , combinatorial chemistry , stereochemistry , photochemistry , cofactor , molecule , biochemistry , dna , organic chemistry , nucleotide , receptor , gene , financial economics , economics , enzyme , catalysis
Potential control : A Ru II ‐bound pterin forms a stable hydrogen‐bonding adduct with a guanine derivative through three‐point recognition. A large positive shift of the reduction potential of the pterin ligand up to +320 mV is observed (see picture). For the thymine derivative, the mode of hydrogen bonding is altered. Regulation of redox potentials of a pterin coenzyme by noncovalent interaction is demonstrated.