Regulation of Redox Potential of a Pterin Derivative Bound to a Ruthenium(II) Complex by Intermolecular Hydrogen Bonding with Nucleobases | Zendy

Inui Yuji | Zendy; Miyazaki Soushi | Zendy; Ohkubo Kei | Zendy; Fukuzumi Shunichi | Zendy; Kojima Takahiko | Zendy

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Regulation of Redox Potential of a Pterin Derivative Bound to a Ruthenium(II) Complex by Intermolecular Hydrogen Bonding with Nucleobases

Author(s) -

Inui Yuji,

Miyazaki Soushi,

Ohkubo Kei,

Fukuzumi Shunichi,

Kojima Takahiko

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201108827

Subject(s) - pterin , ruthenium , chemistry , adduct , hydrogen bond , nucleobase , intermolecular force , guanine , derivative (finance) , redox , ligand (biochemistry) , thymine , combinatorial chemistry , stereochemistry , photochemistry , cofactor , molecule , biochemistry , dna , organic chemistry , nucleotide , receptor , gene , financial economics , economics , enzyme , catalysis

Potential control : A Ru II ‐bound pterin forms a stable hydrogen‐bonding adduct with a guanine derivative through three‐point recognition. A large positive shift of the reduction potential of the pterin ligand up to +320 mV is observed (see picture). For the thymine derivative, the mode of hydrogen bonding is altered. Regulation of redox potentials of a pterin coenzyme by noncovalent interaction is demonstrated.

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