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Synthetic Bio‐nanoreactor: Mechanical and Chemical Control of Polymersome Membrane Permeability
Author(s) -
Gaitzsch Jens,
Appelhans Dietmar,
Wang Linge,
Battaglia Giuseppe,
Voit Brigitte
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201108814
Subject(s) - nanoreactor , polymersome , membrane , transmembrane protein , membrane permeability , nanotechnology , chemistry , combinatorial chemistry , materials science , copolymer , biochemistry , amphiphile , organic chemistry , polymer , nanoparticle , receptor
pH‐sensitive polymersomes have been stabilized by UV cross‐linking after incorporation of an enzyme in a synthetic bio‐nanoreactor without transmembrane proteins. This stabilization allows the reversible swelling and deswelling of the polymersomes upon changes in the pH value. The controlled reaction of the enclosed enzyme could be monitored selectively at pH 6, when the substrate could penetrate the membrane.