Glycomics for Drug Discovery: Metabolic Perturbation in Androgen‐Independent Prostate Cancer Cells Induced by Unnatural Hexosamine Mimics | Zendy

Nishimura ShinIchiro | Zendy; Hato Megumi | Zendy; Hyugaji Satoshi | Zendy; Feng Fei | Zendy; Amano Maho | Zendy

Premium

Glycomics for Drug Discovery: Metabolic Perturbation in Androgen‐Independent Prostate Cancer Cells Induced by Unnatural Hexosamine Mimics

Author(s) -

Nishimura ShinIchiro,

Hato Megumi,

Hyugaji Satoshi,

Feng Fei,

Amano Maho

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201108742

Subject(s) - drug discovery , chemistry , prostate cancer , glycomics , computational biology , glycan , drug , cancer research , biochemistry , biology , cancer , pharmacology , genetics , glycoprotein

Inhibited : N ‐acetylglucosamine (GlcNAc) derivatives with a fluorine atom at the C4 position ( 2 – 4 ) were synthesized, and their ability to inhibit cancer‐cell growth was investigated. The administration of these 4F‐GlcNAc derivatives to cells led to the unnatural sugar nucleotide 1 . Furthermore, N‐glycan profiles of cells were determined by using a glycoblotting‐based enrichment analysis, which is suitable for high‐throughput screenings for drug discovery.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research