Premium
Glycomics for Drug Discovery: Metabolic Perturbation in Androgen‐Independent Prostate Cancer Cells Induced by Unnatural Hexosamine Mimics
Author(s) -
Nishimura ShinIchiro,
Hato Megumi,
Hyugaji Satoshi,
Feng Fei,
Amano Maho
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201108742
Subject(s) - drug discovery , chemistry , prostate cancer , glycomics , computational biology , glycan , drug , cancer research , biochemistry , biology , cancer , pharmacology , genetics , glycoprotein
Inhibited : N ‐acetylglucosamine (GlcNAc) derivatives with a fluorine atom at the C4 position ( 2 – 4 ) were synthesized, and their ability to inhibit cancer‐cell growth was investigated. The administration of these 4F‐GlcNAc derivatives to cells led to the unnatural sugar nucleotide 1 . Furthermore, N‐glycan profiles of cells were determined by using a glycoblotting‐based enrichment analysis, which is suitable for high‐throughput screenings for drug discovery.