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Access to Skipped Polyene Macrolides through Ring‐Closing Metathesis: Total Synthesis of the RNA Polymerase Inhibitor Ripostatin B
Author(s) -
Winter Philipp,
Hiller Wolf,
Christmann Mathias
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201108692
Subject(s) - polyene , total synthesis , ring closing metathesis , stereochemistry , ring (chemistry) , chemistry , salt metathesis reaction , metathesis , closing (real estate) , combinatorial chemistry , biochemistry , organic chemistry , political science , law , polymerization , polymer
Rip‐Roaring! A convergent total synthesis of antibiotic ripostatin B was developed. A key step in the synthesis is a metathesis reaction allowing for a ring closure to the labile doubly skipped triene macrolide.