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Intramolecular Redox‐Triggered CH Functionalization
Author(s) -
Jurberg Igor D.,
Peng Bo,
Wöstefeld Eckhard,
Wasserloos Maximilian,
Maulide Nuno
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201108639
Subject(s) - intramolecular force , surface modification , redox , chemistry , photochemistry , combinatorial chemistry , stereochemistry , organic chemistry
Sacrifice for the team : A one‐pot method achieves remote functionalization at the α‐position of an amine moiety through the sacrificial reduction of a neighboring group. The process takes advantage of an intramolecular redox reaction, thereby avoiding the need for any external oxidants. This method was applied to a concise five‐step total synthesis of indolizidine 167B.