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Inside Cover: A Synthetic Approach Toward a Self‐Regulated Insulin Delivery System (Angew. Chem. Int. Ed. 9/2012)
Author(s) -
Matsumoto Akira,
Ishii Takehiko,
Nishida Junko,
Matsumoto Hiroko,
Kataoka Kazunori,
Miyahara Yuji
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201108617
Subject(s) - cover (algebra) , insulin delivery , insulin , drug delivery , derivative (finance) , int , chemistry , materials science , nanotechnology , computer science , diabetes mellitus , medicine , engineering , endocrinology , type 1 diabetes , business , operating system , mechanical engineering , finance
A totally synthetic artificial pancreas is described by Y. Miyahara et al. in their Communication on page 2124 ff . A hydrogel bearing a phenylboronate derivative undergoes a glucose‐dependent transition in its state of hydration under physiological conditions. The reversible surface‐localized dehydration enables the provision of insulin to be controlled, thus offering a new basis for the treatment of diabetes with long‐term stability and safety.