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A General Solution for the 2‐Pyridyl Problem
Author(s) -
Dick Graham R.,
Woerly Eric M.,
Burke Martin D.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201108608
Subject(s) - aryl , amination , combinatorial chemistry , halide , reagent , chemistry , palladium , catalysis , organic chemistry , alkyl
Problem solved : An air‐stable 2‐pyridyl borane that can effectively couple to a wide range of aryl and heteroaryl halides and pseudohalides has evaded the synthesis community for decades. The discovery that Cu(DEA) 2 powerfully enables palladium‐mediated cross‐couplings with air‐stable boronates 1 has finally provided a general solution to this problem. DEA=diethanolamine, DMF= N , N ′‐dimethylformamide, Tf=trifluoromethanesulfonyl.